Symptoms of Biotin Deficiency

Symptoms of biotin deficiency vary widely because biotin is involved in so many biochemical processes in the body.⁴ Clinical signs may include:

• Anemia.³
• Ataxia.⁷
• Depression.^{1, 5}
• Developmental delays.¹⁸
• Elevated cholesterol levels.³
• Fatigue.^{1, 5}
• Hair loss and thinning hair.^{1, 7}
• Hallucinations.^{1, 5}
• Heart function impairment.^{3, 8}
• Increased number of bacterial and fungal infections due to impaired immunity.^{3, 5}
• Insomnia.³
• Leiner's disease.⁴
• Loss of appetite.³
• Loss of hair color.¹
• Loss of hearing.¹⁰
• Mental retardation.⁷
• Muscle pain.³
• Muscle weakness.⁷
• Numbness, burning, and tingling in arms, legs, hands, and feet.^{1, 3, 5}
• Pallor.³
• 
  Red and scaly skin rash (around eyes, mouth, nose, and genitals); usually tests positive for the yeast infection Candida.¹⁸
• Seizures and other neurological problems.¹⁰
• Sore tongue.³
• Unusual urinary odor.⁴
• Vision problems.¹⁰